Blood test provides new hope to people today with despair | Mental Health and fitness News

A blood exam employing RNA markers is presenting new hope to people with temper problems these kinds of as depression in what could be a major breakthrough in the prognosis of mental well being circumstances.

A group from the US’s Indiana University University of Medication released the blood take a look at in April, claiming it to be psychiatry’s to start with-at any time organic answer to diagnosing a temper dysfunction.

“Our study displays that it is achievable to have a blood exam for depression and bipolar condition, that have scientific utility, can distinguish amongst the two, and match persons to the ideal medications,” stated psychiatrist and geneticist Dr Alexander Niculescu, who led the investigate.

“This avoids a long time of trials and error, hospitalisations, and facet-consequences. As these are quite typical conditions, we feel we can do a large amount of fantastic with this and other tests and apps we have formulated.”

The analyze delved into the biological basis of mood issues, creating a resource to distinguish which kind of mood disorder a particular person has – despair or bipolar condition.

To acquire the check, Dr Niculescu’s team drew on its 15 years of preceding research into how psychiatry relates to blood gene expression biomarkers – measurable indicators of a biological state in the kind of RNA, DNA, proteins or other molecules.

Each and every system in the body – the brain, the anxious process, the immune method – has a prevalent developmental route, states Dr Niculescu.

“For case in point, when you’re pressured or depressed, there are psycho-neurological mechanisms, hormones and other matters that are released that affect your blood and your immune method,” he instructed Al Jazeera.

Conversely, an immune activation or swelling would influence the mind.

Dr Alexander Niculescu and his crew drew on 15 decades of prior exploration to produce the test [Supplied]

In the very first phase of the research, the workforce recognized a list of RNA biomarkers that could monitor temper states above a time period of time. After validating them in an impartial cohort of topics with clinically critical despair and clinically severe mania, they finalised 26 biomarkers, which they whittled down to 12 by further more testing.

With these findings, doctors would be capable to send sufferers to a lab for bloodwork to show the triggers of their signs or symptoms, just as they would for a actual physical ailment, states

Read More.. Read More

Black tech founders work to improve health care for people of color : Shots

(from left) Kevin Dedner founded Hurdle, a mental health startup that pairs patients with therapists. Ashlee Wisdom’s company, Health in Her Hue, connects women of color with culturally sensitive medical providers. Nathan Pelzer’s Clinify Health analyzes data to help doctors identify at-risk patients in underserved areas. Erica Plybeah’s firm, MedHaul, arranges transport to medical appointments.

Kevin Dedner; Kolin Mendez Photography; Aaron Gang Photography; Starboard & Port Creative


hide caption

toggle caption

Kevin Dedner; Kolin Mendez Photography; Aaron Gang Photography; Starboard & Port Creative

(from left) Kevin Dedner founded Hurdle, a mental health startup that pairs patients with therapists. Ashlee Wisdom’s company, Health in Her Hue, connects women of color with culturally sensitive medical providers. Nathan Pelzer’s Clinify Health analyzes data to help doctors identify at-risk patients in underserved areas. Erica Plybeah’s firm, MedHaul, arranges transport to medical appointments.

Kevin Dedner; Kolin Mendez Photography; Aaron Gang Photography; Starboard & Port Creative

When Ashlee Wisdom launched an early version of her health and wellness website, more than 34,000 users — most of them Black — visited the platform in the first two weeks.

“It wasn’t the most fully functioning platform,” recalls Wisdom, 31. “It was not sexy.”

But the launch was successful. Now, more than a year later, Wisdom’s company, Health in Her Hue, connects Black women and other women of color to culturally sensitive doctors, doulas, nurses and therapists nationally.

As more patients seek culturally competent care — the acknowledgment of a patient’s heritage, beliefs and values during treatment — a new wave of Black tech founders like Wisdom want to help. In the same way Uber Eats and Grubhub revolutionized food delivery, Black tech health startups across the United States want to change how people exercise, how they eat and also how they communicate with doctors.

Inspired by their own experiences, plus those of their parents and grandparents, Black entrepreneurs are launching startups that aim to close the cultural gap in health care with technology — and create profitable businesses at the same time.

Seeing problems and solutions others miss

“One of the most exciting growth opportunities across health innovation is to back underrepresented founders building health companies focusing on underserved markets,” says Unity Stoakes, president and co-founder of StartUp Health, a company headquartered in San Francisco that has invested in a number of health companies led by people of color. He says those leaders have “an essential

Read More.. Read More

Social media use linked to despair in older people

Whilst social media has been widely joined to panic and depression in teens, new proof suggests that platforms these types of as TikTok and Instagram can leave middle-aged adults experience unhappy, as well.

The study, printed Tuesday in the healthcare journal JAMA Network Open up, is centered on a sequence of surveys of 5,395 adults whose regular age was 56.

The surveys, conducted from May 2020 by means of May possibly this yr, began as a way for researchers to discover much more about how grownups ended up coping throughout the Covid-19 pandemic.

In excess of time, researchers significantly grew to become interested in no matter whether social media use may possibly be joined to modifications in psychological wellbeing.

“We were being asking individuals who were not frustrated about their social media use,” stated Dr. Roy Perlis, 1 of the study’s authors. “Then we came again later on to see if the men and women who were being utilizing certain types of social media were being far more very likely to be frustrated.”

In contrast to grown ups who did not use social media, “people who were being using Fb, men and women who have been employing TikTok, and people who were being employing Snapchat were being substantially more probably to arrive back again and explain to us they felt frustrated the next time they filled out the study,” said Perlis, a professor of psychiatry at Harvard Medical College and Massachusetts General Hospital.

The analysis does not prove social media results in depression. Without a doubt, it is achievable that persons presently inclined to experience unfortunate were more possible to log on to this sort of web pages.

But it adds to evidence of a escalating mental health and fitness disaster in the United States. Just about one particular-3rd of American older people noted sensation frustrated in an Oct analyze, up from 8.5 percent ahead of the pandemic.

Survey respondents who had minimum signs or symptoms of depression early on were more possible to report an raise in indicators in later on surveys if they utilised social media.

The analysis is restricted in that it can’t tease out what types of information people ended up uncovered to or sought out on-line. And earlier study has revealed an over-all boost in social media use around the past yr.

Exterior professionals theorize that looking at others enjoying lifetime or otherwise

Read More.. Read More

Fasting 2 times a week can aid obese people continue to keep off the fat, research finds

Having said that, the scientists observed that the method, which requires two times of greatly proscribing energy (500 calories for ladies, 600 calories for guys) and 5 times of sensible eating, was rated much more remarkably by the overweight people today in the examine mainly because it was effortless to comply with.

“Listed here we’ve been in a position to supply the first final results on the usefulness of basic 5:2 diet regime guidance in a genuine-everyday living environment. We identified that although the 5:2 diet regime was not superior to traditional techniques in terms of weight loss, buyers chosen this method as it was less difficult and more beautiful,” stated Katie Myers Smith, a chartered wellbeing psychologist and senior exploration fellow at Queen Mary College of London, in a news assertion. She was an creator of the analyze that released in the scientific journal PLOS Just one.

Medical doctors may perhaps want to take into consideration like the 5:2 eating plan as section of their normal weight management advice to individuals, she mentioned.

The research involved 300 overweight people today in Tower Hamlets, an interior city location of higher deprivation in London. The individuals possibly followed the 5:2 program or a extra traditional approach to dropping pounds that pressured taking in far more greens and total-grain meals, reducing out food items higher in sugar and unwanted fat, eating more compact parts and exercise.

‘Modest’ results

The benefits of each approaches were really very similar and “modest,” the examine stated.

At 6 months, those people employing the 5:2 eating plan had shed, on typical, 1.8 kilograms (4 lbs .) as opposed to 1.7 kilograms (3.7 lbs .) on the standard food plan suggestions. At 12 months, people figures were 1.9 kilograms (4.2 lbs) and 1.8 kilograms (4 kilos), respectively.

Some 18% of 5:2 dieters experienced dropped at the very least 5% of their overall body bodyweight right after one calendar year when compared to 15% using the conventional technique.

Of the team pursuing the 5:2 diet regime, 50 percent attended 6 group support sessions for the initially six months soon after the preliminary details session. On the other hand, its influence of the group assist diminished about time, the examine uncovered.

Contributors were being favourable about the different excess weight reduction ways, but all those on the 5:2 eating plan have been much more possible to propose it to others

Read More.. Read More

Pandemic increases mortality risk for people with mental health issues

Share on Pinterest
The pandemic increased mortality rates in people with mental health issues compared with people without. JGI/Tom Grill/Getty Images
  • A study finds that people with mental health issues or intellectual disabilities have been far more likely to die during the pandemic than others.
  • More people in these groups have died of COVID-19 and other causes.
  • There are likely several reasons for this disparity.

According to a new study, people in the U.K. with mental health issues and intellectual disabilities were at about twice the risk of dying than people without those conditions before the COVID-19 pandemic.

The study suggests this difference has increased dramatically during the pandemic, with people with mental health conditions and intellectual disabilities experiencing much higher death rates.

The current study considered “excess deaths,” a general category of deaths during a particular period compared with historical levels.

Says the study’s lead author, Dr. Jayati Das-Munshi of King’s College London in the United Kingdom:

“The results from our study paint a stark picture of how the existing vulnerability of those with mental health conditions and intellectual disabilities has worsened during the COVID-19 pandemic. The higher death rates compared [with] the general population were associated with more deaths from [SARS-CoV-2] infection itself, as well as deaths from other causes.”

Dr. Thomas F. Betzler, executive clinical director of the Montefiore Behavioral Health Center in New York, who was not involved in the study, confirmed for Medical News Today that “many of our patients have similar issues.”

Dr. Das-Munshi says the study’s findings warrant a reappraisal of the groups understood to be at high risk of dying from COVID-19:

“People living with severe mental health conditions and intellectual disabilities should be considered a vulnerable group at risk of COVID-19 mortality — as well as deaths from other causes — throughout the pandemic. We suggest a need to prioritize vaccination and optimize physical healthcare and suicide risk reduction before, during, and after peaks of [SARS-CoV-2] infection in people living with mental health conditions.”

The study appears in The Lancet Regional Health Europe.

The study’s analysis found an increased likelihood of dying among people with mental health issues and intellectual disabilities in the U.K. during the first COVID-19 lockdown compared with the general population.

Specifically, they found that:

  • People with intellectual disabilities were 9.24 times more likely to die of COVID-19.
  • People with eating disorders were 4.81 times
Read More.. Read More

Health care costs for people with rare diseases have been underestimated, study shows

A new, retrospective study of medical and insurance records indicates health care costs for people with a rare disease have been underestimated and are three to five times greater than the costs for people without a rare disease. The study, led by the National Institutes of Health’s National Center for Advancing Translational Sciences (NCATS), provides new evidence of the potential impact of rare diseases on public health, suggesting that nationwide medical costs for individuals with rare diseases are on par with those for cancer and heart failure. The study’s results were published Oct. 21 in the Orphanet Journal of Rare Diseases.

There needs to be greater public awareness of the large and growing medical footprint of rare diseases in society. Only about 10% of rare diseases have an FDA-approved therapy for their treatment. The findings underscore an urgent need for more research, and earlier and more accurate diagnoses of and interventions for these disorders.”


Anne Pariser, M.D., senior author, director, NCATS Office of Rare Diseases Research

Most of the approximately 7,000 to 10,000 known rare diseases disproportionately affect children, adolescents and young adults. Individually, most rare diseases might affect only a few hundred to a few thousand people worldwide. However, rare diseases are collectively common, affecting an estimated 25 million to 30 million people in the United States. Many of these diseases have a genetic cause, are serious or life-threatening and are hard to diagnose and treat.

The pilot study was a collaborative effort among NCATS; Eversana Life Sciences, Chicago; Oregon Health & Science University, Portland; Sanford Health, Sioux Falls, South Dakota; and a health insurer in Australia. Pariser and colleagues analyzed patients’ diagnosis information in medical records and billing codes. They used International Classification of Diseases (ICD) codes, which designate a disease diagnosis and other methods, to determine those individuals with rare diseases and their direct medical costs for 14 rare diseases in four health care systems compared to non-rare disease patients of a similar age.

The pilot study aimed to test the feasibility of this approach in analyzing data on rare diseases prevalence and costs. The 14 rare diseases represented a diverse set of disorders that differ in prevalence, organ systems affected, age of onset, clinical course, and availability of an approved treatment or specific ICD code. Examples of the selected rare diseases include sickle cell disease, muscular dystrophy and eosinophilic esophagitis.

The

Read More.. Read More